Abstract
The adherence of red blood cells (RBC) to endothelial cells (EC), shown to correlate with microvascular occlusion in sickle cell disease and malaria, is considered a major contributor to microcirculatory disorders. In the present study the adherence to EC was markedly enhanced with RBC from β- thalassaemia major (TM) patients, and even more so with RBC from β- thalassaemia intermedia (TI) patients (10-fold and 25-fold higher than normal, respectively). It is proposed that enhanced RBC/EC adherence may contribute to the microcirculatory disorders observed in thalassaemia, especially in TI patients who are particularly known to suffer from leg ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 178-181 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 106 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1999 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Adhesion
- Endothelial cells
- Red blood cells
- β-thalassaemia intermedia
- β-thalassaemia major
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