Enhanced aggregability of red blood cells of β-thalassemia major patients

Shuqi Chen, Amiram Eldor, Gregory Barshtein, Sihua Zhang, Ada Goldfarb, Eliezer Rachmilewitz, Saul Yedgar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

β-Thalassemia major (TM), a congenital hemoglobinopathy, is associated with hemodynamic disorders and with structural red blood cell (RBC) anomalies that may indicate impairment of RBC theological properties. To gain insight into the possible contribution of RBC to the hemodynamic disorders, we studied RBC aggregability, which plays a central role in blood flow, particularly in the microcirculation. RBC aggregate size distribution and morphology of TM RBC were determined using a novel system for image analysis of blood cells in a flow chamber. It was found that the aggregability of RBC of TM patients is markedly enhanced. These cells form large clusters, as opposed to normal rouleaux, and higher shear stress is required to disperse them. The aggregate size of TM RBC is reduced to the normal range after the patients have received a blood transfusion. This study suggests that the hemodynamic disorders observed in TM may be linked to the enhanced RBC aggregability and that improvement of RBC rheological properties may be considered in the treatment of thalassemia.

Original languageAmerican English
Pages (from-to)H1951-H1956
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume270
Issue number6 39-6
DOIs
StatePublished - Jun 1996

Keywords

  • aggregate morphology
  • flow chamber
  • image analysis
  • red cell aggregate size distribution
  • shear stress

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