Enhanced wakefulness following lesions of a mesopontine locus essential for the induction of general anesthesia

Sa'ar Lanir-Azaria, Guy Meiri, Tamir Avigdor, Anne Minert, Marshall Devor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The induction of general anesthesia shares many features with the transition from wakefulness to non-rapid eye movement (NREM) sleep, suggesting that the two types of brain-state transition are orchestrated by a common neuronal mechanism. Previous studies revealed a brainstem locus, the mesopontine tegmental anesthesia area (MPTA), that is of singular importance for anesthetic induction. Microinjection of GABAergic anesthetics there induces rapid loss-of-consciousness and lesions render the animal relatively insensitive to anesthetics administered systemically. Here we show that MPTA lesions also alter the natural sleep-wake rhythm by increasing overall wake time at the expense of time asleep (NREM and REM sleep equally), with nearly all of the change occurring during the dark hours of the light-dark cycle. The effect was proportional to the extent of the lesion and was not seen after lesions just outside of the MPTA, or following sham lesions. Thus, MPTA neurons appear to play a role in natural bistable brain-state switching (sleep-wake) as well as in loss and recovery of consciousness induced pharmacologically.

Original languageAmerican English
Pages (from-to)198-211
Number of pages14
JournalBehavioural Brain Research
StatePublished - 2 Apr 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.


  • Flip-flop switch
  • Insomnia
  • Loss-of-consciousness
  • MPTA
  • Mesopontine tegmentum
  • Reversible coma
  • Sleep


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