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Enhancement of anti-Shigella lipopolysaccharide (LPS) response by addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a LPS vaccines

  • N. Orr*
  • , R. Arnon
  • , G. Rubin
  • , D. Cohen
  • , H. Bercovier
  • , G. H. Lowell
  • *Corresponding author for this work

Research output: Contribution to journalComment/debate

17 Scopus citations

Abstract

Addition of the cholera toxin B subunit to oral and intranasal proteosome- Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.

Original languageEnglish
Pages (from-to)5198-5200
Number of pages3
JournalInfection and Immunity
Volume62
Issue number11
StatePublished - 1994
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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