Enhancement of Class II-restricted T cell responses by costimulatory NK receptors for Class I MHC proteins

Ofer Mandelboim, Daniel M. Davis, Hugh T. Reyburn, Mar Valés-Gómez, Eric G. Sheu, Laszlo Pazmany, Jack L. Strominger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

An important feature of the human immune system is the ability of T cells to respond to small quantities of antigen. Class II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned. In the presence of low doses of superantigen, the proliferative response of these T cell clones was three- to ninefold greater when the T cells were costimulated by way of the NK receptor. Thus, the action of costimulatory NK receptors on T cells may play a significant role in initiating and sustaining immune responses.

Original languageAmerican English
Pages (from-to)2097-2100
Number of pages4
JournalScience
Volume274
Issue number5295
DOIs
StatePublished - 20 Dec 1996
Externally publishedYes

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