Abstract
The undecapeptide Substance P stimulates phagocytosis by mouse macrophages and human polymorphonuclear leukocytes. The activity of Substance P resides in its N-terminal tetrapeptide protion. Substance P and its N-terminal tetrapeptide are as active as tuftsin in their phagocytosis-stimulating activity and compete with tuftsin for its binding sites. The phagocytosis-enhancing activity of Substance P may play a role in inflammatory processes of neural origin where the involvement of the peptide has been implicated.
Original language | English |
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Pages (from-to) | 1445-1451 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 94 |
Issue number | 4 |
DOIs | |
State | Published - 30 Jun 1980 |
Externally published | Yes |