Enhancement of phagocytosis - A newly found activity of Substance P residing in its N-terminal tetrapeptide sequence

Z. Bar-Shavit*, R. Goldman, Y. Stabinsky, P. Gottlieb, M. Fridkin, V. I. Teichberg, S. Blumberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

273 Scopus citations

Abstract

The undecapeptide Substance P stimulates phagocytosis by mouse macrophages and human polymorphonuclear leukocytes. The activity of Substance P resides in its N-terminal tetrapeptide protion. Substance P and its N-terminal tetrapeptide are as active as tuftsin in their phagocytosis-stimulating activity and compete with tuftsin for its binding sites. The phagocytosis-enhancing activity of Substance P may play a role in inflammatory processes of neural origin where the involvement of the peptide has been implicated.

Original languageEnglish
Pages (from-to)1445-1451
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume94
Issue number4
DOIs
StatePublished - 30 Jun 1980
Externally publishedYes

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