Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery

Eli Kedar; Igal Louria-Hayon; Aviva Joseph; Zichria Zakay-Rones; Tomoko Hayashi; Kenji Takabayashi; Yechezkel Barenholz

doi:10.1007/978-1-59259-305-7_16

Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery

Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, Yechezkel Barenholz

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotides’ analogs (ISS-ODN or CpG motifs) are potent stimulators of both innate immunity and specific adaptive immune responses (1–5). Bacterial DNA and ISSODNs directly activate monocytes/macrophages, dendritic cells, natural killer (NK) cells and B cells (6–10), induce the production of proinflammatory cytokines (e.g., IL-6, IL-12, IFNs, TNFa) (4,6,7,11,12), and upregulate the expression of MHC I, MHC II and co-stimulatory molecules (9,13). In animal studies, ISS-ODNs exhibit strong Th1 (2,14–18) and mucosal adjuvanticity to a wide range of antigens (2,3,14,19–26) or allergens (27–30). Furthermore, pretreatment with ISS-ODN, even without concomitant administration of the relevant antigens, can afford protection (for about 2 wk) against subsequent infection with intracellular pathogens (31–35), indicating activation of innate immunity.

Original language	American English
Title of host publication	Microbial DNA and Host Immunity
Editors	Eyal Raz
Place of Publication	Totowa, NJ
Publisher	Humana Press
Pages	203-218
Number of pages	16
ISBN (Print)	978-1-59259-305-7
DOIs	https://doi.org/10.1007/978-1-59259-305-7_16
State	Published - 2002

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title = "Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery",

abstract = "Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotides{\textquoteright} analogs (ISS-ODN or CpG motifs) are potent stimulators of both innate immunity and specific adaptive immune responses (1–5). Bacterial DNA and ISSODNs directly activate monocytes/macrophages, dendritic cells, natural killer (NK) cells and B cells (6–10), induce the production of proinflammatory cytokines (e.g., IL-6, IL-12, IFNs, TNFa) (4,6,7,11,12), and upregulate the expression of MHC I, MHC II and co-stimulatory molecules (9,13). In animal studies, ISS-ODNs exhibit strong Th1 (2,14–18) and mucosal adjuvanticity to a wide range of antigens (2,3,14,19–26) or allergens (27–30). Furthermore, pretreatment with ISS-ODN, even without concomitant administration of the relevant antigens, can afford protection (for about 2 wk) against subsequent infection with intracellular pathogens (31–35), indicating activation of innate immunity.",

author = "Eli Kedar and Igal Louria-Hayon and Aviva Joseph and Zichria Zakay-Rones and Tomoko Hayashi and Kenji Takabayashi and Yechezkel Barenholz",

year = "2002",

doi = "10.1007/978-1-59259-305-7\_16",

language = "American English",

isbn = "978-1-59259-305-7",

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editor = "Eyal Raz",

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publisher = "Humana Press",

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T1 - Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery

AU - Kedar, Eli

AU - Louria-Hayon, Igal

AU - Joseph, Aviva

AU - Zakay-Rones, Zichria

AU - Hayashi, Tomoko

AU - Takabayashi, Kenji

AU - Barenholz, Yechezkel

PY - 2002

Y1 - 2002

N2 - Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotides’ analogs (ISS-ODN or CpG motifs) are potent stimulators of both innate immunity and specific adaptive immune responses (1–5). Bacterial DNA and ISSODNs directly activate monocytes/macrophages, dendritic cells, natural killer (NK) cells and B cells (6–10), induce the production of proinflammatory cytokines (e.g., IL-6, IL-12, IFNs, TNFa) (4,6,7,11,12), and upregulate the expression of MHC I, MHC II and co-stimulatory molecules (9,13). In animal studies, ISS-ODNs exhibit strong Th1 (2,14–18) and mucosal adjuvanticity to a wide range of antigens (2,3,14,19–26) or allergens (27–30). Furthermore, pretreatment with ISS-ODN, even without concomitant administration of the relevant antigens, can afford protection (for about 2 wk) against subsequent infection with intracellular pathogens (31–35), indicating activation of innate immunity.

AB - Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotides’ analogs (ISS-ODN or CpG motifs) are potent stimulators of both innate immunity and specific adaptive immune responses (1–5). Bacterial DNA and ISSODNs directly activate monocytes/macrophages, dendritic cells, natural killer (NK) cells and B cells (6–10), induce the production of proinflammatory cytokines (e.g., IL-6, IL-12, IFNs, TNFa) (4,6,7,11,12), and upregulate the expression of MHC I, MHC II and co-stimulatory molecules (9,13). In animal studies, ISS-ODNs exhibit strong Th1 (2,14–18) and mucosal adjuvanticity to a wide range of antigens (2,3,14,19–26) or allergens (27–30). Furthermore, pretreatment with ISS-ODN, even without concomitant administration of the relevant antigens, can afford protection (for about 2 wk) against subsequent infection with intracellular pathogens (31–35), indicating activation of innate immunity.

U2 - 10.1007/978-1-59259-305-7_16

DO - 10.1007/978-1-59259-305-7_16

M3 - Chapter

SN - 978-1-59259-305-7

SP - 203

EP - 218

BT - Microbial DNA and Host Immunity

A2 - Raz, Eyal

PB - Humana Press

CY - Totowa, NJ

ER -

Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence By Liposomal Delivery

Abstract

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