Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing

Israel Alshanski; Moshe Bentolila; Agata Gitlin-Domagalska; Dolev Zamir; Shir Zorsky; Salim Joubran; Mattan Hurevich; Chaim Gilon

doi:10.1021/acs.oprd.8b00225

Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing

Israel Alshanski, Moshe Bentolila, Agata Gitlin-Domagalska, Dolev Zamir, Shir Zorsky, Salim Joubran, Mattan Hurevich^*, Chaim Gilon

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.

Original language	English
Pages (from-to)	1318-1322
Number of pages	5
Journal	Organic Process Research and Development
Volume	22
Issue number	9
DOIs	https://doi.org/10.1021/acs.oprd.8b00225
State	Published - 21 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

Keywords

High shear
SPPS
mixing
solid support

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10.1021/acs.oprd.8b00225

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abstract = "The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.",

keywords = "High shear, SPPS, mixing, solid support",

author = "Israel Alshanski and Moshe Bentolila and Agata Gitlin-Domagalska and Dolev Zamir and Shir Zorsky and Salim Joubran and Mattan Hurevich and Chaim Gilon",

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AU - Alshanski, Israel

AU - Bentolila, Moshe

AU - Gitlin-Domagalska, Agata

AU - Zamir, Dolev

AU - Zorsky, Shir

AU - Joubran, Salim

AU - Hurevich, Mattan

AU - Gilon, Chaim

PY - 2018/9/21

Y1 - 2018/9/21

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AB - The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.

KW - High shear

KW - SPPS

KW - mixing

KW - solid support

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SN - 1083-6160

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Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing

Abstract

Bibliographical note

Keywords

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