Enhancing the Efficiency of the Solid Phase Peptide Synthesis (SPPS) Process by High Shear Mixing

Israel Alshanski, Moshe Bentolila, Agata Gitlin-Domagalska, Dolev Zamir, Shir Zorsky, Salim Joubran, Mattan Hurevich*, Chaim Gilon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The brittle nature of the polymer beads used in SPPS dictates mild mixing techniques with low mass transfer. We demonstrate that vigorous overhead mechanical stirring with superior mass transfer properties kept the beads intact and significantly accelerates reaction kinetics and efficiency.

Original languageAmerican English
Pages (from-to)1318-1322
Number of pages5
JournalOrganic Process Research and Development
Volume22
Issue number9
DOIs
StatePublished - 21 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

Keywords

  • High shear
  • SPPS
  • mixing
  • solid support

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