Abstract
Salmon calcitonin (sCT) is a polypeptide hormone available in the clinic. sCT is degraded in the gastrointestinal tract in minutes. In this work, a stapled analogue of salmon calcitonin, KaY-1(R24Q), was developed using the cooperative stapling between Lys and Tyr, with R24Q substitution. The analogue exhibited an improved stability in simulated gastric and intestinal fluid and retained the ability to activate the calcitonin receptor. This work will serve as a starting point for the development of an oral sCT drug.
| Original language | English |
|---|---|
| Pages (from-to) | 6682-6685 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 59 |
| Issue number | 44 |
| DOIs | |
| State | Published - 26 Apr 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Royal Society of Chemistry.