Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases

Mark P. Running, Meirav Lavy, Hasana Sternberg, Arnaud Galichet, Wilhelm Gruissem*, Sarah Hake, Naomi Ori, Shaul Yalovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Meristems require a myriad of intercellular signaling pathways for coordination of cell division within and between functional zones and clonal cell layers. This control of cell division ensures a constant availability of stem cells throughout the life span of the meristem while limiting overproliferation of meristematic cells and maintaining the meristem structure. We have undertaken a genetic screen to identify additional components of meristem signaling pathways. We identified pluripetala (plp) mutants based on their dramatically larger meristems and increased floral organ number. PLURIPETALA encodes the α-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. plp mutants also have altered abscisic acid responses and overall much slower growth rate. plp is epistatic to mutations in the α-subunit of farnesyltransferase and shows a synergistic interaction with clavata3 mutants. plp mutants lead to insights into the mechanism of meristem homeostasis and provide a unique in vivo system for studying the functional role of prenylation in eukaryotes.

Original languageAmerican English
Pages (from-to)7815-7820
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number20
DOIs
StatePublished - 18 May 2004

Fingerprint

Dive into the research topics of 'Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases'. Together they form a unique fingerprint.

Cite this