Enteropathogenic E. coli exploitation of host epithelial cells

B. Brett Finlay*, Sharon Ruschkowski, Brendan Kenny, Markus Stein, Dieter J. Reinscheid, Murry A. Stein, Ilan Rosenshine

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Enteropathogenic E. coli (EPEC) is a leading cause of neonatal diarrhea worldwide. These organisms adhere to the intestinal cell surface, causing rearrangement in the epithelial cell surface and underlying cytoskeleton, resulting in a structure termed an attaching/effacing (A/E) lesion. A/E lesion formation is thought necessary for EPEC-mediated disease. EPEC secretes several proteins that trigger signal transduction, intimate adherence, and cytoskeletal rearrangements in epithelial cells. Additionally, it produces intimin, an outer membrane product that mediates intimate adherence. Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea.

Original languageAmerican English
Pages (from-to)26-31
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume797
DOIs
StatePublished - 1996

Bibliographical note

Funding Information:
We thank Dr. N. J. Cowan for the kind gift of samples of TCP-1 chaperonin and the I3-actin:chaperonin complex. We thank Dr. J. M. Carazo and R. Marabini for allowing us the use of their unpublished classification methods and their careful reading of the manuscript. This work was partly supported by Grant PB91-0109 from the Direcci6n General de Investigaci6n Cientifica y T6cnica. S.M. is a recipient of a fellowship from the Comunidad Aut6noma de Madrid.

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