Enthalpically driven peptide stabilization by protective osmolytes

Regina Politi; Daniel Harries

doi:10.1039/c0cc01763a

Enthalpically driven peptide stabilization by protective osmolytes

Regina Politi
, Daniel Harries^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native β-hairpin state. In contrast to entropically driven steric "crowding", this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.

Original language	English
Pages (from-to)	6449-6451
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	35
DOIs	https://doi.org/10.1039/c0cc01763a
State	Published - 21 Sep 2010

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10.1039/c0cc01763a

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Enthalpically driven peptide stabilization by protective osmolytes

Abstract

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