Environment dominates over host genetics in shaping human gut microbiota

Daphna Rothschild; Omer Weissbrod; Elad Barkan; Alexander Kurilshikov; Tal Korem; David Zeevi; Paul I. Costea; Anastasia Godneva; Iris N. Kalka; Noam Bar; Smadar Shilo; Dar Lador; Arnau Vich Vila; Niv Zmora; Meirav Pevsner-Fischer; David Israeli; Noa Kosower; Gal Malka; Bat Chen Wolf; Tali Avnit-Sagi; Maya Lotan-Pompan; Adina Weinberger; Zamir Halpern; Shai Carmi; Jingyuan Fu; Cisca Wijmenga; Alexandra Zhernakova; Eran Elinav; Eran Segal

doi:10.1038/nature25973

Environment dominates over host genetics in shaping human gut microbiota

Daphna Rothschild, Omer Weissbrod, Elad Barkan, Alexander Kurilshikov, Tal Korem, David Zeevi, Paul I. Costea, Anastasia Godneva, Iris N. Kalka, Noam Bar, Smadar Shilo, Dar Lador, Arnau Vich Vila, Niv Zmora, Meirav Pevsner-Fischer, David Israeli, Noa Kosower, Gal Malka, Bat Chen Wolf, Tali Avnit-SagiMaya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shai Carmi, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Eran Elinav^*, Eran Segal

^*Corresponding author for this work

Department of Social Medicine

Research output: Contribution to journal › Article › peer-review

1816 Scopus citations

Abstract

Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.

Original language	English
Pages (from-to)	210-215
Number of pages	6
Journal	Nature
Volume	555
Issue number	7695
DOIs	https://doi.org/10.1038/nature25973
State	Published - 8 Mar 2018

Bibliographical note

Publisher Copyright:
© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nature25973

Cite this

Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., Shilo, S., Lador, D., Vila, A. V., Zmora, N., Pevsner-Fischer, M., Israeli, D., Kosower, N., Malka, G., Wolf, B. C., ... Segal, E. (2018). Environment dominates over host genetics in shaping human gut microbiota. Nature, 555(7695), 210-215. https://doi.org/10.1038/nature25973

@article{180d40a4d6bf46769a4bce51ea74456f,

title = "Environment dominates over host genetics in shaping human gut microbiota",

abstract = "Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.",

author = "Daphna Rothschild and Omer Weissbrod and Elad Barkan and Alexander Kurilshikov and Tal Korem and David Zeevi and Costea, {Paul I.} and Anastasia Godneva and Kalka, {Iris N.} and Noam Bar and Smadar Shilo and Dar Lador and Vila, {Arnau Vich} and Niv Zmora and Meirav Pevsner-Fischer and David Israeli and Noa Kosower and Gal Malka and Wolf, {Bat Chen} and Tali Avnit-Sagi and Maya Lotan-Pompan and Adina Weinberger and Zamir Halpern and Shai Carmi and Jingyuan Fu and Cisca Wijmenga and Alexandra Zhernakova and Eran Elinav and Eran Segal",

year = "2018",

month = mar,

day = "8",

doi = "10.1038/nature25973",

language = "אנגלית",

volume = "555",

pages = "210--215",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "7695",

}

Rothschild, D, Weissbrod, O, Barkan, E, Kurilshikov, A, Korem, T, Zeevi, D, Costea, PI, Godneva, A, Kalka, IN, Bar, N, Shilo, S, Lador, D, Vila, AV, Zmora, N, Pevsner-Fischer, M, Israeli, D, Kosower, N, Malka, G, Wolf, BC, Avnit-Sagi, T, Lotan-Pompan, M, Weinberger, A, Halpern, Z, Carmi, S, Fu, J, Wijmenga, C, Zhernakova, A, Elinav, E & Segal, E 2018, 'Environment dominates over host genetics in shaping human gut microbiota', Nature, vol. 555, no. 7695, pp. 210-215. https://doi.org/10.1038/nature25973

TY - JOUR

T1 - Environment dominates over host genetics in shaping human gut microbiota

AU - Rothschild, Daphna

AU - Weissbrod, Omer

AU - Barkan, Elad

AU - Kurilshikov, Alexander

AU - Korem, Tal

AU - Zeevi, David

AU - Costea, Paul I.

AU - Godneva, Anastasia

AU - Kalka, Iris N.

AU - Bar, Noam

AU - Shilo, Smadar

AU - Lador, Dar

AU - Vila, Arnau Vich

AU - Zmora, Niv

AU - Pevsner-Fischer, Meirav

AU - Israeli, David

AU - Kosower, Noa

AU - Malka, Gal

AU - Wolf, Bat Chen

AU - Avnit-Sagi, Tali

AU - Lotan-Pompan, Maya

AU - Weinberger, Adina

AU - Halpern, Zamir

AU - Carmi, Shai

AU - Fu, Jingyuan

AU - Wijmenga, Cisca

AU - Zhernakova, Alexandra

AU - Elinav, Eran

AU - Segal, Eran

PY - 2018/3/8

Y1 - 2018/3/8

N2 - Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.

AB - Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.

UR - http://www.scopus.com/inward/record.url?scp=85043351358&partnerID=8YFLogxK

U2 - 10.1038/nature25973

DO - 10.1038/nature25973

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 29489753

AN - SCOPUS:85043351358

SN - 0028-0836

VL - 555

SP - 210

EP - 215

JO - Nature

JF - Nature

IS - 7695

ER -

Environment dominates over host genetics in shaping human gut microbiota

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this