Enzymatic ring-opening mechanism of verdoheme by the heme oxygenase: A combined X-ray crystallography and QM/MM study

Keyphrases

• X-ray Crystallography 100%
• Verdoheme 100%
• Ring-opening Mechanism 100%
• Heme Oxygenase 100%
• QM/MM Calculations 100%
• FeOOH 25%
• Biliverdin 16%
• Water Clusters 16%
• Hydrogen Peroxide 8%
• Reaction Mechanism 8%
• Azides 8%
• Electron Transfer 8%
• Assure 8%
• Spectral Analysis 8%
• Biocatalyst 8%
• Crystallization 8%
• Anaerobic Conditions 8%
• Rate-determining Step 8%
• Proton Transfer 8%
• Nucleophile 8%
• Iron Homeostasis 8%
• Ring Opening 8%
• Bond Breaking 8%
• X-ray Diffraction Measurement 8%
• Air-sensitive 8%
• Proton Shuttle 8%
• Corynebacterium Diphtheriae 8%
• Complex Crystal 8%
• Homolytic 8%
• Heme Degradation 8%
• CRISTAL 8%
• Combined Study 8%

Chemistry

• X-Ray Crystallography 100%
• Ring Opening Reaction 100%
• Heme Oxygenase 100%
• Biliverdin 66%
• Crystal Structure 33%
• Azide 33%
• X-Ray Diffraction 33%
• Nucleophile 33%
• Hydrogen Peroxide 33%
• Proton Transfer 33%
• Biocatalyst 33%
• Rate-Determining Step 33%
• Heme 33%