Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Reut Harel; Israel Gavish; Ariel Aviv; Nofar Greenman Maravi; Philippe Trougouboff; Ari Zimran; Shoshana Revel-Vilk

doi:10.1111/imj.15781

Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Reut Harel^*
, Israel Gavish
, Ariel Aviv
, Nofar Greenman Maravi
, Philippe Trougouboff
, Ari Zimran
, Shoshana Revel-Vilk

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41-year-old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase-alfa significantly improved myeloma indices.

Original language	English
Pages (from-to)	872-875
Number of pages	4
Journal	Internal Medicine Journal
Volume	52
Issue number	5
DOIs	https://doi.org/10.1111/imj.15781
State	Published - May 2022

Bibliographical note

Publisher Copyright:
© 2022 Royal Australasian College of Physicians.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gaucher disease
enzyme replacement therapy
monoclonal gammopathy of unknown significance (MGUS)
multiple myeloma
polyclonal gammopathy

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10.1111/imj.15781

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title = "Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease",

abstract = "Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41-year-old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase-alfa significantly improved myeloma indices.",

keywords = "Gaucher disease, enzyme replacement therapy, monoclonal gammopathy of unknown significance (MGUS), multiple myeloma, polyclonal gammopathy",

author = "Reut Harel and Israel Gavish and Ariel Aviv and \{Greenman Maravi\}, Nofar and Philippe Trougouboff and Ari Zimran and Shoshana Revel-Vilk",

note = "Publisher Copyright: {\textcopyright} 2022 Royal Australasian College of Physicians.",

year = "2022",

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T1 - Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

AU - Harel, Reut

AU - Gavish, Israel

AU - Aviv, Ariel

AU - Greenman Maravi, Nofar

AU - Trougouboff, Philippe

AU - Zimran, Ari

AU - Revel-Vilk, Shoshana

PY - 2022/5

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N2 - Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41-year-old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase-alfa significantly improved myeloma indices.

AB - Patients with Gaucher disease (GD) have been shown previously to carry an increased risk for cancer, most commonly multiple myeloma (MM). It is currently unknown whether treatment for GD has an effect on the prevention or amelioration of MM. We present the case of a 41-year-old patient simultaneously diagnosed with GD and smouldering MM. Enzyme replacement therapy with Velaglucerase-alfa significantly improved myeloma indices.

KW - Gaucher disease

KW - enzyme replacement therapy

KW - monoclonal gammopathy of unknown significance (MGUS)

KW - multiple myeloma

KW - polyclonal gammopathy

UR - https://www.scopus.com/pages/publications/85129699007

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DO - 10.1111/imj.15781

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VL - 52

SP - 872

EP - 875

JO - Internal Medicine Journal

JF - Internal Medicine Journal

IS - 5

ER -

Enzyme replacement therapy leading to improvement in myeloma indices in a patient with concomitant Gaucher disease

Abstract

Bibliographical note

UN SDGs

Keywords

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