Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

John T. Groves; Ronny Neumann

doi:10.1021/jo00251a054

Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

John T. Groves, Ronny Neumann

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.

Original language	English
Pages (from-to)	3891-3893
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	53
Issue number	16
DOIs	https://doi.org/10.1021/jo00251a054
State	Published - 1 Aug 1988
Externally published	Yes

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abstract = "The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.",

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N2 - The hydroxylation of simple alkanes and the selective C-25 hydroxylation of cholesterol have been achieved with a membrane-spanning Mn(III) porphyrin positioned in a synthetic bilayer assembly by appended steroidal substituents.

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Enzymic Regioselectivity in the Hydroxylation of Cholesterol Catalyzed by a Membrane-Spanning Metalloporphyrin

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