Eosinophils interaction with mast cells: The allergic effector unit

Roopesh Singh Gangwar, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

11 Scopus citations

Abstract

Mast cells (MC) and eosinophils are the key effector cells of allergy (Minai-Fleminger and Levi-Schaffer, Inflamm Res 58:631-638, 2009). In general, allergic reactions have two phases, namely, an early phase and a late phase. MC and eosinophils abundantly coexist in the inflamed tissue in the late and chronic phases and cross talk in a bidirectional manner. This bidirectional interaction between MC and eosinophils is mediated by both physical cell-cell contacts through cell surface receptors such as CD48 receptors CD48, 2B4, 2B4 and soluble mediators through various specific granular mediators, arachidonic acid metabolites, cytokines cytokines, and chemokines, collectively termed the "Allergic Effector Unit" (AEU) (Elishmereni et al., Allergy 66:376-385, 2011; Minai-Fleminger et al., Cell Tissue Res 341:405-415, 2010). These bidirectional interactions can be studied in vitro in a customized coculture system of MC and eosinophils derived from either mouse or human source.

Original languageAmerican English
Title of host publicationEosinophils
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages231-249
Number of pages19
ISBN (Print)9781493910151
DOIs
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
Volume1178
ISSN (Print)1064-3745

Keywords

  • Allergic Effector Unit
  • BMEos
  • BMMC
  • Coculture
  • Mast cell-eosinophil interactions
  • Murine AEU

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