Epigenetic control of recombination in the immune system

Yehudit Bergman; Howard Cedar

doi:10.1016/j.smim.2010.07.003

Epigenetic control of recombination in the immune system

Yehudit Bergman^*, Howard Cedar

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.

Original language	English
Pages (from-to)	323-329
Number of pages	7
Journal	Seminars in Immunology
Volume	22
Issue number	6
DOIs	https://doi.org/10.1016/j.smim.2010.07.003
State	Published - Dec 2010

Bibliographical note

Funding Information:
This work was supported by grants from the Israel Academy of Science (Y.B. and H.C.) and the National Institutes of Health (Y.B. and H.C.), the Israel Cancer Research Fund (Y.B. and H.C.), the European Community F16 Marie Curie (Y.B.) and the Lew Sanders Fund (H.C.).

Keywords

Asynchronous DNA replication
Chromatin accessibility
DNA methylation
Locus contraction and decontraction
V(D)J rearrangement

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10.1016/j.smim.2010.07.003

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abstract = "Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.",

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author = "Yehudit Bergman and Howard Cedar",

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AB - Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.

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KW - Chromatin accessibility

KW - DNA methylation

KW - Locus contraction and decontraction

KW - V(D)J rearrangement

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Epigenetic control of recombination in the immune system

Abstract

Bibliographical note

Keywords

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