Epigenetic control of recombination in the immune system

Yehudit Bergman*, Howard Cedar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.

Original languageAmerican English
Pages (from-to)323-329
Number of pages7
JournalSeminars in Immunology
Issue number6
StatePublished - Dec 2010

Bibliographical note

Funding Information:
This work was supported by grants from the Israel Academy of Science (Y.B. and H.C.) and the National Institutes of Health (Y.B. and H.C.), the Israel Cancer Research Fund (Y.B. and H.C.), the European Community F16 Marie Curie (Y.B.) and the Lew Sanders Fund (H.C.).


  • Asynchronous DNA replication
  • Chromatin accessibility
  • DNA methylation
  • Locus contraction and decontraction
  • V(D)J rearrangement


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