TY - JOUR
T1 - Epigenetic control of recombination in the immune system
AU - Bergman, Yehudit
AU - Cedar, Howard
PY - 2010/12
Y1 - 2010/12
N2 - Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.
AB - Immune receptor gene expression is regulated by a series of developmental events that modify their accessibility in a locus, cell type, stage and allele-specific manner. This is carried out by a programmed combination of many different molecular mechanisms, including region-wide replication timing, changes in nuclear localization, chromatin contraction, histone modification, nucleosome positioning and DNA methylation. These modalities ultimately work by controlling steric interactions between receptor loci and the recombination machinery.
KW - Asynchronous DNA replication
KW - Chromatin accessibility
KW - DNA methylation
KW - Locus contraction and decontraction
KW - V(D)J rearrangement
UR - https://www.scopus.com/pages/publications/78249266271
U2 - 10.1016/j.smim.2010.07.003
DO - 10.1016/j.smim.2010.07.003
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C2 - 20832333
AN - SCOPUS:78249266271
SN - 1044-5323
VL - 22
SP - 323
EP - 329
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 6
ER -