Epigenetic mechanisms that regulate antigen receptor gene expression

Yehudit Bergman*, Amanda Fisher, Howard Cedar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Functional immunoglobulin and T-cell receptor genes are generated from germline V, D and J gene segments by a series of site-specific recombination events. This process is regulated by the availability of recombination machinery and by the ordered accessibility of appropriate target gene segments. Recent studies highlight the importance of chromatin remodelling and locus positioning for controlling antigen receptor gene expression and recombination.

Original languageAmerican English
Pages (from-to)176-181
Number of pages6
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 2003


Dive into the research topics of 'Epigenetic mechanisms that regulate antigen receptor gene expression'. Together they form a unique fingerprint.

Cite this