TY - JOUR
T1 - Epigenetic pathways regulating bone homeostasis:Potential targeting for intervention of skeletal disorders
AU - Gordon, Jonathan A.R.
AU - Montecino, Martin A.
AU - Aqeilan, Rami I.
AU - Stein, Janet L.
AU - Stein, Gary S.
AU - Lian, Jane B.
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2014.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Epigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells that are independent of DNA sequence, including DNA silencing, posttranslational modifications of histone proteins, and the posttranscriptional modulation of RNA transcript levels by noncoding RNAs.Although long non-coding RNAs have recently emerged as important regulators of gene imprinting, their functions during osteogenesis are as yet unexplored.In contrast, microRNAs (miRNAs) are well characterized for their control of osteogenic and osteoclastic pathways; thus, further defining how gene regulatory networks essential for skeleton functions are coordinated and finely tuned through the activities of miRNAs.Roles of miRNAs are constantly expanding as new studies uncover associations with skeletal disorders.The distinct functions of epigenetic regulators and evidence for integrating their activities to control normal bone gene expression and bone disease will be presented.In addition, potential for using “signature miRNAs” to identify, manage, and therapeutically treat osteosarcoma will be discussed in this review.
AB - Epigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells that are independent of DNA sequence, including DNA silencing, posttranslational modifications of histone proteins, and the posttranscriptional modulation of RNA transcript levels by noncoding RNAs.Although long non-coding RNAs have recently emerged as important regulators of gene imprinting, their functions during osteogenesis are as yet unexplored.In contrast, microRNAs (miRNAs) are well characterized for their control of osteogenic and osteoclastic pathways; thus, further defining how gene regulatory networks essential for skeleton functions are coordinated and finely tuned through the activities of miRNAs.Roles of miRNAs are constantly expanding as new studies uncover associations with skeletal disorders.The distinct functions of epigenetic regulators and evidence for integrating their activities to control normal bone gene expression and bone disease will be presented.In addition, potential for using “signature miRNAs” to identify, manage, and therapeutically treat osteosarcoma will be discussed in this review.
KW - DNAmethylation
KW - Epigenetic marks in bone
KW - Histonemodifications
KW - Osteoblast regulation
KW - Osteosarcoma miRNAs
KW - miRNA
UR - http://www.scopus.com/inward/record.url?scp=84918541907&partnerID=8YFLogxK
U2 - 10.1007/s11914-014-0240-1
DO - 10.1007/s11914-014-0240-1
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C2 - 25260661
AN - SCOPUS:84918541907
SN - 1544-1873
VL - 12
SP - 496
EP - 506
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
IS - 4
ER -
