Epigenomics and the structure of the living genome

Nir Friedman*, Oliver J. Rando

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

Eukaryotic genomes are packaged into an extensively folded state known as chromatin. Analysis of the structure of eukaryotic chromosomes has been revolutionized by development of a suite of genome-wide measurement technologies, collectively termed "epigenomics." We review major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding at scales ranging from whole chromosome folding down to nucleotide-resolution assays that provide structural insights into protein-DNA interactions. We then briefly outline several challenges remaining and highlight new developments such as single-cell epigenomic assays that will help provide us with a high-resolution structural understanding of eukaryotic genomes.

Original languageAmerican English
Pages (from-to)1482-1490
Number of pages9
JournalGenome Research
Volume25
Issue number10
DOIs
StatePublished - 1 Oct 2015

Bibliographical note

Publisher Copyright:
© 2015 Friedman and Rando.

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