TY - JOUR
T1 - Epithelial-mesenchymal transition in ovarian carcinoma
AU - Davidson, Ben
AU - Tropé, Claes G.
AU - Reich, Reuven
PY - 2012
Y1 - 2012
N2 - Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression. However, ovarian carcinomas, constituting the vast majority of ovarian cancers, additionally have unique biology, one aspect of which is the ability to co-express epithelial and mesenchymal determinants. epithelial-mesenchymal transition (EMT), a physiological process by which mesenchymal cells are formed and migrate to target organs during embryogenesis, is involved in cancer cell invasion and metastasis. However, these changes do not fully occur in ovarian carcinoma, and are even reversed in tumor cells present in malignant peritoneal and pleural effusions. This review summarizes current knowledge in this area, including the characteristics of EMT related to adhesion, transcriptional regulation and chemoresistance, and their clinical relevance, as well as the recently observed regulation of EMT by microRNA.
AB - Ovarian cancer is the most lethal gynecologic malignancy, with the majority of patients dying within 5 years of diagnosis. This poor survival of patients diagnosed with this malignancy is attributed to diagnosis at advanced stage, when the tumor has metastasized, and to chemotherapy resistance, either primary or developing along tumor progression. However, ovarian carcinomas, constituting the vast majority of ovarian cancers, additionally have unique biology, one aspect of which is the ability to co-express epithelial and mesenchymal determinants. epithelial-mesenchymal transition (EMT), a physiological process by which mesenchymal cells are formed and migrate to target organs during embryogenesis, is involved in cancer cell invasion and metastasis. However, these changes do not fully occur in ovarian carcinoma, and are even reversed in tumor cells present in malignant peritoneal and pleural effusions. This review summarizes current knowledge in this area, including the characteristics of EMT related to adhesion, transcriptional regulation and chemoresistance, and their clinical relevance, as well as the recently observed regulation of EMT by microRNA.
KW - Chemotherapy
KW - Epithelial-mesenchymal transition
KW - Mesenchymal-epithelial transition
KW - Metastasis
KW - Ovarian carcinoma
KW - Prognosis
KW - Tumor progression
UR - http://www.scopus.com/inward/record.url?scp=84870233792&partnerID=8YFLogxK
U2 - 10.3389/fonc.2012.00033
DO - 10.3389/fonc.2012.00033
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AN - SCOPUS:84870233792
SN - 2234-943X
VL - 2
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - APR
M1 - 00033
ER -