Epithelial–mesenchymal transitions during neural crest and somite development

Chaya Kalcheim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Epithelial-to-mesenchymal transition (EMT) is a central process during embryonic development that affects selected progenitor cells of all three germ layers. In addition to driving the onset of cellular migrations and subsequent tissue morphogenesis, the dynamic conversions of epithelium into mesenchyme and vice-versa are intimately associated with the segregation of homogeneous precursors into distinct fates. The neural crest and somites, progenitors of the peripheral nervous system and of skeletal tissues, respectively, beautifully illustrate the significance of EMT to the above processes. Ongoing studies progressively elucidate the gene networks underlying EMT in each system, highlighting the similarities and differences between them. Knowledge of the mechanistic logic of this normal ontogenetic process should provide important insights to the understanding of pathological conditions such as cancer metastasis, which shares some common molecular themes.

Original languageAmerican English
JournalJournal of Clinical Medicine
Volume5
Issue number1
DOIs
StatePublished - 25 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 by the authors.

Keywords

  • BMP
  • Cell fate
  • Cell migration
  • Dermis
  • Dermomyotome
  • FGF
  • N-cadherin
  • Neural tube
  • Sclerotome
  • Wnt

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