TY - JOUR
T1 - Erythrocyte survival is controlled by microRNA-142
AU - Rivkin, Natalia
AU - Chapnik, Elik
AU - Mildner, Alexander
AU - Barshtein, Gregory
AU - Porat, Ziv
AU - Kartvelishvily, Elena
AU - Dadosh, Tali
AU - Birger, Yehudit
AU - Amir, Gail
AU - Yedgar, Saul
AU - Izraeli, Shai
AU - Jung, Steffen
AU - Hornstein, Eran
N1 - Publisher Copyright:
© 2017 Ferrata Storti Foundation.
PY - 2017/3/31
Y1 - 2017/3/31
N2 - Hematopoietic–specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-func-tion allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for the normal metabolism of reactive oxygen species, and for overall lifespan. microRNA-142 further controls ACTIN filament homeostasis and membrane skeleton organization. The analyses presented reveal previously unappreciated functions of microRNA-142 and contribute to an emerging view of small RNAs as key players in erythropoiesis. Finally, the work herein demonstrates how a housekeeping network of cytoskeletal regulators can be reshaped by a single micro-RNA denominator in a cell type specific manner.
AB - Hematopoietic–specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-func-tion allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for the normal metabolism of reactive oxygen species, and for overall lifespan. microRNA-142 further controls ACTIN filament homeostasis and membrane skeleton organization. The analyses presented reveal previously unappreciated functions of microRNA-142 and contribute to an emerging view of small RNAs as key players in erythropoiesis. Finally, the work herein demonstrates how a housekeeping network of cytoskeletal regulators can be reshaped by a single micro-RNA denominator in a cell type specific manner.
UR - http://www.scopus.com/inward/record.url?scp=85016994194&partnerID=8YFLogxK
U2 - 10.3324/haematol.2016.156109
DO - 10.3324/haematol.2016.156109
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C2 - 27909218
AN - SCOPUS:85016994194
SN - 0390-6078
VL - 102
SP - 676
EP - 685
JO - Haematologica
JF - Haematologica
IS - 4
ER -