Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

Ronen Hazan, Boaz Sat, Hanna Engelberg-Kulka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

230 Scopus citations

Abstract

mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

Original languageAmerican English
Pages (from-to)3663-3669
Number of pages7
JournalJournal of Bacteriology
Volume186
Issue number11
DOIs
StatePublished - Jun 2004

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