TY - JOUR
T1 - Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions
AU - Hazan, Ronen
AU - Sat, Boaz
AU - Engelberg-Kulka, Hanna
PY - 2004/6
Y1 - 2004/6
N2 - mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
AB - mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
UR - http://www.scopus.com/inward/record.url?scp=2442696541&partnerID=8YFLogxK
U2 - 10.1128/JB.186.11.3663-3669.2004
DO - 10.1128/JB.186.11.3663-3669.2004
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C2 - 15150257
AN - SCOPUS:2442696541
SN - 0021-9193
VL - 186
SP - 3663
EP - 3669
JO - Journal of Bacteriology
JF - Journal of Bacteriology
IS - 11
ER -
