Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

Ronen Hazan; Boaz Sat; Hanna Engelberg-Kulka

doi:10.1128/JB.186.11.3663-3669.2004

Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

Ronen Hazan
, Boaz Sat
, Hanna Engelberg-Kulka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

243 Scopus citations

Abstract

mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

Original language	English
Pages (from-to)	3663-3669
Number of pages	7
Journal	Journal of Bacteriology
Volume	186
Issue number	11
DOIs	https://doi.org/10.1128/JB.186.11.3663-3669.2004
State	Published - Jun 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/JB.186.11.3663-3669.2004

Cite this

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abstract = "mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.",

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AB - mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

UR - https://www.scopus.com/pages/publications/2442696541

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Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions

Abstract

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