Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Meir Wilchek*, Edward A. Bayer, Oded Livnah

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

192 Scopus citations

Abstract

Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

Original languageAmerican English
Pages (from-to)27-32
Number of pages6
JournalImmunology Letters
Volume103
Issue number1
DOIs
StatePublished - 28 Feb 2006

Keywords

  • Avidin
  • Catalysis
  • Protein-ligand
  • Protein-protein
  • Streptavidin

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