Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Meir Wilchek; Edward A. Bayer; Oded Livnah

doi:10.1016/j.imlet.2005.10.022

Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Meir Wilchek^*, Edward A. Bayer, Oded Livnah

^*Corresponding author for this work

Department of Biological Chemistry

Research output: Contribution to journal › Review article › peer-review

194 Scopus citations

Abstract

Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Immunology Letters
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.10.022
State	Published - 28 Feb 2006

Keywords

Avidin
Catalysis
Protein-ligand
Protein-protein
Streptavidin

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10.1016/j.imlet.2005.10.022

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AU - Livnah, Oded

PY - 2006/2/28

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AB - Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

KW - Avidin

KW - Catalysis

KW - Protein-ligand

KW - Protein-protein

KW - Streptavidin

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Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

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Keywords

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