Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Meir Wilchek; Edward A. Bayer; Oded Livnah

doi:10.1016/j.imlet.2005.10.022

Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Meir Wilchek^*, Edward A. Bayer, Oded Livnah

^*Corresponding author for this work

Department of Biological Chemistry

Research output: Contribution to journal › Review article › peer-review

198 Scopus citations

Abstract

Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

Original language	English
Pages (from-to)	27-32
Number of pages	6
Journal	Immunology Letters
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.10.022
State	Published - 28 Feb 2006

Keywords

Avidin
Catalysis
Protein-ligand
Protein-protein
Streptavidin

Access to Document

10.1016/j.imlet.2005.10.022

Cite this

@article{7bd99d5594d04070a1dabeca15e1880c,

title = "Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction",

abstract = "Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.",

keywords = "Avidin, Catalysis, Protein-ligand, Protein-protein, Streptavidin",

author = "Meir Wilchek and Bayer, \{Edward A.\} and Oded Livnah",

year = "2006",

month = feb,

day = "28",

doi = "10.1016/j.imlet.2005.10.022",

language = "אנגלית",

volume = "103",

pages = "27--32",

journal = "Immunology Letters",

issn = "0165-2478",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Essentials of biorecognition

T2 - The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

AU - Wilchek, Meir

AU - Bayer, Edward A.

AU - Livnah, Oded

PY - 2006/2/28

Y1 - 2006/2/28

N2 - Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

AB - Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions.

KW - Avidin

KW - Catalysis

KW - Protein-ligand

KW - Protein-protein

KW - Streptavidin

UR - https://www.scopus.com/pages/publications/31544481163

U2 - 10.1016/j.imlet.2005.10.022

DO - 10.1016/j.imlet.2005.10.022

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 16325268

AN - SCOPUS:31544481163

SN - 0165-2478

VL - 103

SP - 27

EP - 32

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this