Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors

Itzhak Katzir; Jashovam Shani; Dalia Shabashov; Judith Dagan; Philip Lazarovici

doi:10.1016/S0304-3835(03)00414-2

Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors

Itzhak Katzir, Jashovam Shani, Dalia Shabashov, Judith Dagan, Philip Lazarovici^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To date experimental in vivo pheochromocytoma (PC) models have not been available. A major in vitro PC model consists of PC12 cells that respond to nerve growth factor (NGF) by differentiation, mediated by the trkA receptor. We report the establishment of PC12 tumor models expressing low and high levels of trkA receptor in CD1 nude mice. The tumors are characterized by their responsiveness to NGF, karyotype, presence of enolase, and chromaffin granules, as well as dopamine release. These novel PC models facilitate research on the role of the trkA receptor in cancer and the development of trkA-selective anti-cancer agents.

Original language	English
Pages (from-to)	177-185
Number of pages	9
Journal	Cancer Letters
Volume	200
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00414-2
State	Published - 28 Oct 2003

Keywords

Characterization
Pheochromocytoma
TrkA-receptor overexpression
Tumorogenicity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(03)00414-2

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abstract = "To date experimental in vivo pheochromocytoma (PC) models have not been available. A major in vitro PC model consists of PC12 cells that respond to nerve growth factor (NGF) by differentiation, mediated by the trkA receptor. We report the establishment of PC12 tumor models expressing low and high levels of trkA receptor in CD1 nude mice. The tumors are characterized by their responsiveness to NGF, karyotype, presence of enolase, and chromaffin granules, as well as dopamine release. These novel PC models facilitate research on the role of the trkA receptor in cancer and the development of trkA-selective anti-cancer agents.",

keywords = "Characterization, Pheochromocytoma, TrkA-receptor overexpression, Tumorogenicity",

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T1 - Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors

AU - Katzir, Itzhak

AU - Shani, Jashovam

AU - Shabashov, Dalia

AU - Dagan, Judith

AU - Lazarovici, Philip

PY - 2003/10/28

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N2 - To date experimental in vivo pheochromocytoma (PC) models have not been available. A major in vitro PC model consists of PC12 cells that respond to nerve growth factor (NGF) by differentiation, mediated by the trkA receptor. We report the establishment of PC12 tumor models expressing low and high levels of trkA receptor in CD1 nude mice. The tumors are characterized by their responsiveness to NGF, karyotype, presence of enolase, and chromaffin granules, as well as dopamine release. These novel PC models facilitate research on the role of the trkA receptor in cancer and the development of trkA-selective anti-cancer agents.

AB - To date experimental in vivo pheochromocytoma (PC) models have not been available. A major in vitro PC model consists of PC12 cells that respond to nerve growth factor (NGF) by differentiation, mediated by the trkA receptor. We report the establishment of PC12 tumor models expressing low and high levels of trkA receptor in CD1 nude mice. The tumors are characterized by their responsiveness to NGF, karyotype, presence of enolase, and chromaffin granules, as well as dopamine release. These novel PC models facilitate research on the role of the trkA receptor in cancer and the development of trkA-selective anti-cancer agents.

KW - Characterization

KW - Pheochromocytoma

KW - TrkA-receptor overexpression

KW - Tumorogenicity

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Establishment and characterization of pheochromocytoma tumor models expressing different levels of trkA receptors

Abstract

Keywords

UN SDGs

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