Establishment of methylation patterns in ES cells

Ofra Sabag, Ayelet Zamir, Ilana Keshet, Merav Hecht, Guy Ludwig, Amalia Tabib, Joshua Moss, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

After erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at implantation. We have identified a demethylation pathway in mouse embryonic cells that uses hydroxymethylation (Tet1), deamination (Aid), glycosylation (Mbd4) and excision repair (Gadd45a) genes. Surprisingly, this demethylation system is not necessary for generating the overall bimodal methylation pattern but does appear to be involved in resetting methylation patterns during somatic-cell reprogramming.

Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalNature Structural and Molecular Biology
Volume21
Issue number1
DOIs
StatePublished - Jan 2014

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