Estimation of dissolution rate of salicylamide in complexing media using a theoretical diffusion model

M. Donbrow*, E. Touitou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Dissolution rates of salicylamide in water and caffeine solutions under perfect sink conditions were predicted by theoretical diffusion equations applicable to dissolution in complexing media. Experimental dissolution rates were measured using a compartmentalized rotating‐basket apparatus under two sets of conditions. Agreement was found between experimental and predicted rates. Use of the theoretical equation for estimating dissolution rates involves simple calculations of diffusion coefficients and diffusion layer thickness under the operative dissolution conditions. The increase in dissolution rate caused by addition of the complexant can be calculated for diffusion‐controlled dissolution directly if the stability constant and the drug solubility in water are known or measured.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume67
Issue number1
DOIs
StatePublished - Jan 1978

Keywords

  • Complexes—salicylamide and caffeine, dissolution rates estimated using theoretical diffusion model, compared to experimental results
  • Diffusion model, theoretical—used to estimate dissolution rates of salicylamide in water and caffeine solutions, compared to experimental results
  • Dissolution rates—salicylamide in water and caffeine solutions, estimated using theoretical diffusion model, compared to experimental results
  • Salicylamide—dissolution rates in water and caffeine solutions, estimated using theoretical diffusion model, compared to experimental results

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