TY - JOUR
T1 - Evaluation of iron‐chelating agents in an in vivo system
T2 - potential usefulness of EHPG, a powerful iron‐chelating drug
AU - Hershko, Chaim
AU - Grady, Robert W.
AU - Link, Gabriela
PY - 1982/6
Y1 - 1982/6
N2 - Summary. Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron‐chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine‐N,N′‐bis(o‐hydroxyphenylglycine) (EHPG). EHPG‐induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF). Studies employing selective radio‐iron probes of reticuloendothelial and parenchymal iron stores showed that although EHPG is able to interact with both storage iron compartments, its effect on parenchymal iron is much more pronounced. Unlike DF which has two alternative routes of excretion, EHPG‐induced iron excretion is restricted mainly to the gut. Although EHPG seems to be superior to DF in both its chelating efficiency and preferential interaction with hepatic parenchymal iron stores, information on its in vivo toxicity is at present insufficient and it cannot yet be recommended for clinical use.
AB - Summary. Fifteen compounds with a high affinity to ferric iron have been screened for in vivo iron‐chelating efficiency in a rat model. One of the most potent of these drugs was ethylenediamine‐N,N′‐bis(o‐hydroxyphenylglycine) (EHPG). EHPG‐induced iron excretion was up to 8 times higher than iron excretion induced by identical doses of desferrioxamine (DF). Studies employing selective radio‐iron probes of reticuloendothelial and parenchymal iron stores showed that although EHPG is able to interact with both storage iron compartments, its effect on parenchymal iron is much more pronounced. Unlike DF which has two alternative routes of excretion, EHPG‐induced iron excretion is restricted mainly to the gut. Although EHPG seems to be superior to DF in both its chelating efficiency and preferential interaction with hepatic parenchymal iron stores, information on its in vivo toxicity is at present insufficient and it cannot yet be recommended for clinical use.
UR - http://www.scopus.com/inward/record.url?scp=0019989126&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.1982.tb08482.x
DO - 10.1111/j.1365-2141.1982.tb08482.x
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C2 - 7082583
AN - SCOPUS:0019989126
SN - 0007-1048
VL - 51
SP - 251
EP - 260
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -