Evaluation of ophthalmic and hemodynamic parameters in capuchin monkeys (Sapajus sp.) submitted to dissociative anesthetic protocols

A. C.S. Raposo, R. Ofri, D. P.H. Schaffer, D. C. Gomes Júnior, F. A. Libório, E. F. Martins Filho, A. P. Oriá*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic parameters in 24 capuchin monkeys subjected to four dissociative anesthesia protocols. Methods: Animals were anesthetized with tiletamine-zolazepam (TZ), ketamine-xylazine (KX), ketamine-midazolam (KM), or ketamine-dexmedetomidine (KD). Muscle relaxation, digital reflex, lacrimal production, intraocular pressure (IOP), heart and respiratory rates, oxygen saturation (SpO2), rectal temperature, non-invasive arterial blood pressure, palpebral and pupillary reflexes, and eyeball positioning were evaluated every 5 minutes for 20 minutes. Results: Muscle relaxation was highest in KM and KD. At 5-minute post-injection, IOP was higher in TZ than in all other groups. There was a significant difference between groups and times in heart and respiratory rates and temperature. There were no significant differences in SpO2, arterial blood pressure, and lacrimal production between groups. Conclusions: The established parameters may help in clinical and ophthalmic examinations of primates.

Original languageAmerican English
Pages (from-to)381-389
Number of pages9
JournalJournal of Medical Primatology
Volume44
Issue number6
DOIs
StatePublished - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 John Wiley & Sons A/S.

Keywords

  • Dexmedetomidine
  • Intraocular pressure
  • Ketamine
  • Lacrimal production
  • Midazolam
  • Tiletamine-zolazepam
  • Xylazine

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