TY - JOUR
T1 - Evaluation of ophthalmic and hemodynamic parameters in capuchin monkeys (Sapajus sp.) submitted to dissociative anesthetic protocols
AU - Raposo, A. C.S.
AU - Ofri, R.
AU - Schaffer, D. P.H.
AU - Gomes Júnior, D. C.
AU - Libório, F. A.
AU - Martins Filho, E. F.
AU - Oriá, A. P.
N1 - Publisher Copyright:
© 2015 John Wiley & Sons A/S.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic parameters in 24 capuchin monkeys subjected to four dissociative anesthesia protocols. Methods: Animals were anesthetized with tiletamine-zolazepam (TZ), ketamine-xylazine (KX), ketamine-midazolam (KM), or ketamine-dexmedetomidine (KD). Muscle relaxation, digital reflex, lacrimal production, intraocular pressure (IOP), heart and respiratory rates, oxygen saturation (SpO2), rectal temperature, non-invasive arterial blood pressure, palpebral and pupillary reflexes, and eyeball positioning were evaluated every 5 minutes for 20 minutes. Results: Muscle relaxation was highest in KM and KD. At 5-minute post-injection, IOP was higher in TZ than in all other groups. There was a significant difference between groups and times in heart and respiratory rates and temperature. There were no significant differences in SpO2, arterial blood pressure, and lacrimal production between groups. Conclusions: The established parameters may help in clinical and ophthalmic examinations of primates.
AB - Background: Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic parameters in 24 capuchin monkeys subjected to four dissociative anesthesia protocols. Methods: Animals were anesthetized with tiletamine-zolazepam (TZ), ketamine-xylazine (KX), ketamine-midazolam (KM), or ketamine-dexmedetomidine (KD). Muscle relaxation, digital reflex, lacrimal production, intraocular pressure (IOP), heart and respiratory rates, oxygen saturation (SpO2), rectal temperature, non-invasive arterial blood pressure, palpebral and pupillary reflexes, and eyeball positioning were evaluated every 5 minutes for 20 minutes. Results: Muscle relaxation was highest in KM and KD. At 5-minute post-injection, IOP was higher in TZ than in all other groups. There was a significant difference between groups and times in heart and respiratory rates and temperature. There were no significant differences in SpO2, arterial blood pressure, and lacrimal production between groups. Conclusions: The established parameters may help in clinical and ophthalmic examinations of primates.
KW - Dexmedetomidine
KW - Intraocular pressure
KW - Ketamine
KW - Lacrimal production
KW - Midazolam
KW - Tiletamine-zolazepam
KW - Xylazine
UR - http://www.scopus.com/inward/record.url?scp=84958755883&partnerID=8YFLogxK
U2 - 10.1111/jmp.12200
DO - 10.1111/jmp.12200
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C2 - 26457384
AN - SCOPUS:84958755883
SN - 0047-2565
VL - 44
SP - 381
EP - 389
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
IS - 6
ER -