Evaluation of oxazaborolidine activity on Streptococcus mutans biofilm formation

Adel Jabbour, Morris Srebnik, Batia Zaks, Valerie Dembitsky, Doron Steinberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Dental diseases are among the most prevalent afflictions of humankind. These diseases are associated with the formation of biofilms harbouring pathogenic bacteria. Eight different derivatives of oxazaborolidines were synthesised and evaluated for their affect on Streptococcus mutans adhesion and biofilm formation. Structure-activity relationship was observed. The B-butyl moiety of the oxazaborolidines contributed an anti-adhesion effect for all derivatives, whilst its effect diminished when the boron atom was incorporated in a fused heterocyclic ring. The B-phenyl group induced bacterial adhesion in all tested compounds Oxazaborolidines may serve as novel agents for affecting oral biofilm formation. Moreover, the ability to alter the oxazaborolidine molecule and thus affect biofilms offers an excellent opportunity to study biofilm formation.

Original languageAmerican English
Pages (from-to)491-496
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Issue number6
StatePublished - Dec 2005
Externally publishedYes

Bibliographical note

Funding Information:
This research was funded in part by the Israel Science Foundation. This study is part of the PhD dissertation of Adel Jabbour.


  • Biofilm
  • Dental
  • Oxazaborolidines
  • Streptococcus mutans


Dive into the research topics of 'Evaluation of oxazaborolidine activity on Streptococcus mutans biofilm formation'. Together they form a unique fingerprint.

Cite this