Evaluation of oxazaborolidine activity on Streptococcus mutans biofilm formation

Dental diseases are among the most prevalent afflictions of humankind. These diseases are associated with the formation of biofilms harbouring pathogenic bacteria. Eight different derivatives of oxazaborolidines were synthesised and evaluated for their affect on Streptococcus mutans adhesion and biofilm formation. Structure-activity relationship was observed. The B-butyl moiety of the oxazaborolidines contributed an anti-adhesion effect for all derivatives, whilst its effect diminished when the boron atom was incorporated in a fused heterocyclic ring. The B-phenyl group induced bacterial adhesion in all tested compounds Oxazaborolidines may serve as novel agents for affecting oral biofilm formation. Moreover, the ability to alter the oxazaborolidine molecule and thus affect biofilms offers an excellent opportunity to study biofilm formation.