Evaluation of Sex Differences in the Potential of D9-Tetrahydrocannabinol, Cannabidiol, Cannabidiolic Acid, and Oleoyl Alanine to Reduce Nausea-Induced Conditioned Gaping Reactions in Sprague-Dawley Rats

Erin M. Rock, Cheryl L. Limebeer, Reem Smoum, Raphael Mechoulam, Linda A. Parker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Cancer patients report nausea as a side effect of their chemotherapy treatment. Using the preclinical rodent model of acute nausea—lithium chloride (LiCl)-induced conditioned gaping—our group has demonstrated that exogenous cannabinoids may have antinausea potential. Materials and Methods: With the goal of evaluating the role of sex as a factor in pre-clinical research, we first compared the conditioned gaping reactions produced by varying doses of LiCl in male and female rats using the taste reactivity test (Experiment 1). Results: LiCl produced dose-dependent conditioned gaping similarly in male and female rats with the highest dose (127.2 mg/kg) producing robust conditioned gaping, with this dose used in subsequent experiments. Next, we examined the antinausea potential of THC (Experiment 2), CBD (Experiment 3), cannabidiolic acid (CBDA; Experiment 4) and oleoyl alanine (OlAla; Experiment 5) in both male and female rats. THC, CBD, CBDA, and OlAla dose dependently reduced conditioned gaping in both male and female rats in a similar manner. Conclusions: These results suggest that cannabinoids may be equally effective in treating nausea in both males and females.

Original languageAmerican English
Pages (from-to)1060-1068
Number of pages9
JournalCannabis and Cannabinoid Research
Volume8
Issue number6
DOIs
StatePublished - 1 Dec 2023

Bibliographical note

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Keywords

  • cannabinoid
  • conditioned gaping
  • oleoyl alanine
  • sex differences

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