Evidence for a differential visual M300 brain response in gamblers

Noam Zilberman; Yair Dor Ziderman; Maor Zeev-Wolf; Abraham Goldstein; Gal Yadid; Yehuda Neumark; Yuri Rassovsky

doi:10.1016/j.clinph.2018.08.010

Evidence for a differential visual M300 brain response in gamblers

Noam Zilberman, Yair Dor Ziderman, Maor Zeev-Wolf, Abraham Goldstein, Gal Yadid, Yehuda Neumark, Yuri Rassovsky^*

^*Corresponding author for this work

Department of Social Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Objective: Gambling disorder is the first behavioral addiction recognized in the DSM-5. This marks the growing realization that both behavioral and substance-related addictions are manifestations of an ‘addicted brain’ displaying similar altered neurophysiological mechanisms. A decreased electrophysiological visual P300 is considered a hallmark effect of substance-related addictions, but has not yet been shown in behavioral addictions. Methods: Magnetoencephalographic recordings of 15 gamblers and 17 controls were taken as they performed a cue-reactivity paradigm in which they passively viewed addiction- and non-addiction-related cues. Results: The main finding of the study is a reduction in the magnetic counterpart of P300 (M300) for gamblers beyond cue condition over frontal regions. Additionally, we found a significant group by cue-type interaction. Gamblers exhibited heightened sensitivity to addiction-related cues in regions corresponding to the frontoparietal attentional network, whereas controls exhibited an opposite effect localized to the right insula. Conclusions: The results suggest that a reduced P300 characterizes addictions in general, not just substance-related addictions, thus providing important neurophysiological support for the inclusion of behavioral addictions in the DSM-5 and in the incentive-sensitization theory. Significance: The study offers important insights into neural mechanisms underlying behavioral addictions, and may assist in developing better prevention and intervention strategies.

Original language	American English
Pages (from-to)	2228-2238
Number of pages	11
Journal	Clinical Neurophysiology
Volume	129
Issue number	11
DOIs	https://doi.org/10.1016/j.clinph.2018.08.010
State	Published - Nov 2018

Bibliographical note

Funding Information:
This work was supported by a grant from the Israel Anti-Drug Authority to Prof. Rassovsky. Prof. Gal Yadid serves as the Chair of the Research Committee for the Israel Anti-Drug Authority. The funding agency had no involvement in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. None of the other authors have any potential conflicts of interest regarding this research.

Publisher Copyright:
© 2018 International Federation of Clinical Neurophysiology

Keywords

Addiction
Cue-reactivity
Gambling disorder
Incentive-sensitization
MEG
P300

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10.1016/j.clinph.2018.08.010

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title = "Evidence for a differential visual M300 brain response in gamblers",

abstract = "Objective: Gambling disorder is the first behavioral addiction recognized in the DSM-5. This marks the growing realization that both behavioral and substance-related addictions are manifestations of an {\textquoteleft}addicted brain{\textquoteright} displaying similar altered neurophysiological mechanisms. A decreased electrophysiological visual P300 is considered a hallmark effect of substance-related addictions, but has not yet been shown in behavioral addictions. Methods: Magnetoencephalographic recordings of 15 gamblers and 17 controls were taken as they performed a cue-reactivity paradigm in which they passively viewed addiction- and non-addiction-related cues. Results: The main finding of the study is a reduction in the magnetic counterpart of P300 (M300) for gamblers beyond cue condition over frontal regions. Additionally, we found a significant group by cue-type interaction. Gamblers exhibited heightened sensitivity to addiction-related cues in regions corresponding to the frontoparietal attentional network, whereas controls exhibited an opposite effect localized to the right insula. Conclusions: The results suggest that a reduced P300 characterizes addictions in general, not just substance-related addictions, thus providing important neurophysiological support for the inclusion of behavioral addictions in the DSM-5 and in the incentive-sensitization theory. Significance: The study offers important insights into neural mechanisms underlying behavioral addictions, and may assist in developing better prevention and intervention strategies.",

keywords = "Addiction, Cue-reactivity, Gambling disorder, Incentive-sensitization, MEG, P300",

author = "Noam Zilberman and {Dor Ziderman}, Yair and Maor Zeev-Wolf and Abraham Goldstein and Gal Yadid and Yehuda Neumark and Yuri Rassovsky",

note = "Funding Information: This work was supported by a grant from the Israel Anti-Drug Authority to Prof. Rassovsky. Prof. Gal Yadid serves as the Chair of the Research Committee for the Israel Anti-Drug Authority. The funding agency had no involvement in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. None of the other authors have any potential conflicts of interest regarding this research. Publisher Copyright: {\textcopyright} 2018 International Federation of Clinical Neurophysiology",

year = "2018",

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doi = "10.1016/j.clinph.2018.08.010",

language = "American English",

volume = "129",

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AU - Dor Ziderman, Yair

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AU - Goldstein, Abraham

AU - Yadid, Gal

AU - Neumark, Yehuda

AU - Rassovsky, Yuri

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N2 - Objective: Gambling disorder is the first behavioral addiction recognized in the DSM-5. This marks the growing realization that both behavioral and substance-related addictions are manifestations of an ‘addicted brain’ displaying similar altered neurophysiological mechanisms. A decreased electrophysiological visual P300 is considered a hallmark effect of substance-related addictions, but has not yet been shown in behavioral addictions. Methods: Magnetoencephalographic recordings of 15 gamblers and 17 controls were taken as they performed a cue-reactivity paradigm in which they passively viewed addiction- and non-addiction-related cues. Results: The main finding of the study is a reduction in the magnetic counterpart of P300 (M300) for gamblers beyond cue condition over frontal regions. Additionally, we found a significant group by cue-type interaction. Gamblers exhibited heightened sensitivity to addiction-related cues in regions corresponding to the frontoparietal attentional network, whereas controls exhibited an opposite effect localized to the right insula. Conclusions: The results suggest that a reduced P300 characterizes addictions in general, not just substance-related addictions, thus providing important neurophysiological support for the inclusion of behavioral addictions in the DSM-5 and in the incentive-sensitization theory. Significance: The study offers important insights into neural mechanisms underlying behavioral addictions, and may assist in developing better prevention and intervention strategies.

AB - Objective: Gambling disorder is the first behavioral addiction recognized in the DSM-5. This marks the growing realization that both behavioral and substance-related addictions are manifestations of an ‘addicted brain’ displaying similar altered neurophysiological mechanisms. A decreased electrophysiological visual P300 is considered a hallmark effect of substance-related addictions, but has not yet been shown in behavioral addictions. Methods: Magnetoencephalographic recordings of 15 gamblers and 17 controls were taken as they performed a cue-reactivity paradigm in which they passively viewed addiction- and non-addiction-related cues. Results: The main finding of the study is a reduction in the magnetic counterpart of P300 (M300) for gamblers beyond cue condition over frontal regions. Additionally, we found a significant group by cue-type interaction. Gamblers exhibited heightened sensitivity to addiction-related cues in regions corresponding to the frontoparietal attentional network, whereas controls exhibited an opposite effect localized to the right insula. Conclusions: The results suggest that a reduced P300 characterizes addictions in general, not just substance-related addictions, thus providing important neurophysiological support for the inclusion of behavioral addictions in the DSM-5 and in the incentive-sensitization theory. Significance: The study offers important insights into neural mechanisms underlying behavioral addictions, and may assist in developing better prevention and intervention strategies.

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JF - Clinical Neurophysiology

IS - 11

ER -

Evidence for a differential visual M300 brain response in gamblers

Abstract

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Keywords

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