TY - JOUR
T1 - Evidence for genetic determination in human twins of olfactory thresholds for a standard odorant
AU - Gross-Isseroff, Ruth
AU - Ophir, Dov
AU - Bartana, Atida
AU - Voet, Hillary
AU - Lancet, Doron
PY - 1992/7/6
Y1 - 1992/7/6
N2 - Olfactory thresholds for four odorants were determined in groups of monozygotic and dizygotic human twins. Odorants were presented in an ascending dilution series in odorless solvent, using a three-way forced choice method. For two of the tested odorants, 5α-androst-16-en-3-one and isoamyl acetate, the thresholds showed a strong genetic component. This was demonstrated by respective values of 0.78 and 0.73 for the intraclass correlation difference, and of z = 3.69 and z = 2.71 in a within-pair difference analysis. The results for isoamyl acetate are novel, and suggest that genetic polymorphism in the affinity of odorant receptor proteins contributes to the (nearly normal) threshold distribution for this odorant.
AB - Olfactory thresholds for four odorants were determined in groups of monozygotic and dizygotic human twins. Odorants were presented in an ascending dilution series in odorless solvent, using a three-way forced choice method. For two of the tested odorants, 5α-androst-16-en-3-one and isoamyl acetate, the thresholds showed a strong genetic component. This was demonstrated by respective values of 0.78 and 0.73 for the intraclass correlation difference, and of z = 3.69 and z = 2.71 in a within-pair difference analysis. The results for isoamyl acetate are novel, and suggest that genetic polymorphism in the affinity of odorant receptor proteins contributes to the (nearly normal) threshold distribution for this odorant.
KW - Androstenone
KW - Genetic determination
KW - Individual difference
KW - Isoamyl acetate
KW - Olfactory threshold
KW - Twins
UR - http://www.scopus.com/inward/record.url?scp=0026766084&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(92)90347-A
DO - 10.1016/0304-3940(92)90347-A
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C2 - 1508392
AN - SCOPUS:0026766084
SN - 0304-3940
VL - 141
SP - 115
EP - 118
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -