Evidence for grid-cell-like activity in the time domain

Gregory Peters-Founshtein*, Amnon Dafni-Merom, Rotem Monsa, Shahar Arzy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The relation between the processing of space and time in the brain has been an enduring cross-disciplinary question. Grid cells have been recognized as a hallmark of the mammalian navigation system, with recent studies attesting to their involvement in the organization of conceptual knowledge in humans. To determine whether grid-cell-like representations support temporal processing, we asked subjects to mentally simulate changes in age and time-of-day, each constituting “trajectory” in an age-day space, while undergoing fMRI. We found that grid-cell-like representations supported trajecting across this age-day space. Furthermore, brain regions concurrently coding past-to-future orientation positively modulated the magnitude of grid-cell-like representation in the left entorhinal cortex. Finally, our findings suggest that temporal processing may be supported by spatially modulated systems, and that innate regularities of abstract domains may interface and alter grid-cell-like representations, similarly to spatial geometry.

Original languageAmerican English
Article number108878
JournalNeuropsychologia
Volume198
DOIs
StatePublished - 6 Jun 2024

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Cognitive maps
  • Entorhinal cortex
  • Grid-code
  • Navigation
  • fMRI

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