TY - JOUR
T1 - Evidence for new enantiospecific interaction force in chiral biomolecules
AU - Kapon, Yael
AU - Saha, Abhijit
AU - Duanis-Assaf, Tal
AU - Stuyver, Thijs
AU - Ziv, Amir
AU - Metzger, Tzuriel
AU - Yochelis, Shira
AU - Shaik, Sason
AU - Naaman, Ron
AU - Reches, Meital
AU - Paltiel, Yossi
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/10/14
Y1 - 2021/10/14
N2 - Enantiospecific biorecognition interactions are key to many biological events. Commonly, bio-affinity values, measured in these processes, are higher than those calculated by available methods. We report here the first direct measurement of the interaction force between two chiral peptides (right- and left-handed helical polyalanine peptides) and the quantification of difference in the interaction force between homochiral and heterochiral pairs of molecules using atomic force microscope (AFM), together with supportive calculations based on a simple theoretical model. A force difference of 70 pN between same and opposite enantiomer interactions is measured. Additional measurements show spin dependency and fast decay of the interaction term, consistent with spin exchange interactions. This short range enantiospecific interaction term is especially relevant in crowded biological systems. The results shed light on the importance of spin and exchange interactions in biological processes.
AB - Enantiospecific biorecognition interactions are key to many biological events. Commonly, bio-affinity values, measured in these processes, are higher than those calculated by available methods. We report here the first direct measurement of the interaction force between two chiral peptides (right- and left-handed helical polyalanine peptides) and the quantification of difference in the interaction force between homochiral and heterochiral pairs of molecules using atomic force microscope (AFM), together with supportive calculations based on a simple theoretical model. A force difference of 70 pN between same and opposite enantiomer interactions is measured. Additional measurements show spin dependency and fast decay of the interaction term, consistent with spin exchange interactions. This short range enantiospecific interaction term is especially relevant in crowded biological systems. The results shed light on the importance of spin and exchange interactions in biological processes.
KW - SDG3: Good health and well-being
KW - SDG9: Industry innovation and infrastructure
KW - biorecognition
KW - chiral-induced spin selectivity
KW - enantioselectivity
KW - exchange interaction
KW - protein folding
UR - http://www.scopus.com/inward/record.url?scp=85120602082&partnerID=8YFLogxK
U2 - 10.1016/j.chempr.2021.08.002
DO - 10.1016/j.chempr.2021.08.002
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AN - SCOPUS:85120602082
SN - 2451-9308
VL - 7
SP - 2787
EP - 2799
JO - Chem
JF - Chem
IS - 10
ER -
