Evidence for taste persistence of sweeteners in baboon monkeys: A proposed experimental model

Mouth presaturation of baboon monkeys by the sweeteners neohesperidin dihydrochalcone (NHDHC) or talin produced a significantly increased water intake response during a 15 s period compared with presaturation by either sucrose or aspartame. The magnitude of this water intake response depended upon the concentration of NHDHC and talin during mouth presaturation and upon time intervals between presaturation by NHDHC and water presentation. The intake of solutions containing various concentrations of either NHDHC, talin, aspartame or sucrose after mouth presaturation by the control 0.15 M sucrose solution, resulted in a normal dose-response preference curve for all sweeteners. The intake of 0.15 M sucrose solution was not affected by the nature or by the concentration of sweeteners applied during mouth presaturation.