Evidence for the presence of 'Ouabain like' compound in human cerebrospinal fluid

D. Lichstein*, D. Minc, A. Bourrit, J. Deutsch, S. J.D. Karlish, H. Belmaker, R. Rimon, J. Palo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Material extracted and partially purified from human cerebrospinal fluid (CSF) is capable of: a, inhibiting [3H]ouabain binding to rat brain synaptosomes; b, inhibiting the activity of purified pig kidney Na+,K+-ATPase; and c, inhibiting ouabain sensitive induced 86Rb influx to tissue cultured fibroblasts. These results demonstrate the existence of an 'ouabain like' compound (OLC) in human CSF, and are consistent with the hypothesis of the function of this compound as a neuromodulator.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalBrain Research
Volume325
Issue number1-2
DOIs
StatePublished - 28 Jan 1985

Keywords

  • cardiac glycosides
  • cerebrospinal fluid
  • Na,K-ATPase
  • natriuretic hormone
  • neuromodulators
  • ouabain like compounds

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