Evolution of new regulatory functions on biophysically realistic fitness landscapes

Tamar Friedlander, Roshan Prizak, Nicholas H. Barton, Gašper Tkačik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Gene expression is controlled by networks of regulatory proteins that interact specifically with external signals and DNA regulatory sequences. These interactions force the network components to co-evolve so as to continually maintain function. Yet, existing models of evolution mostly focus on isolated genetic elements. In contrast, we study the essential process by which regulatory networks grow: the duplication and subsequent specialization of network components. We synthesize a biophysical model of molecular interactions with the evolutionary framework to find the conditions and pathways by which new regulatory functions emerge. We show that specialization of new network components is usually slow, but can be drastically accelerated in the presence of regulatory crosstalk and mutations that promote promiscuous interactions between network components.

Original languageAmerican English
Article number216
JournalNature Communications
Issue number1
StatePublished - 1 Dec 2017

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© 2017 The Author(s).


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