Evolution under antibiotic treatments: Interplay between antibiotic persistence, tolerance, and resistance

Nathalie Q. Balaban*, Jiafeng Liu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

In this chapter, we describe the experimental evolution of antibiotic tolerance and persistence under antibiotic treatments and how these phenomena can speed up the subsequent evolution of resistance. The first two parts are dedicated to defining the difference between antibiotic resistance, tolerance, and persistence with qualitative definitions and quantitative metrics. The third part describes experimental observations of the evolution of tolerance and persistence under antibiotic treatments. The fourth part shows that tolerance and persistence speed up the evolution of antibiotic resistance. In each part, mathematical subsections can be skipped by the reader without losing the qualitative understanding of the effects.

Original languageAmerican English
Title of host publicationPersister Cells and Infectious Disease
PublisherSpringer International Publishing
Pages1-17
Number of pages17
ISBN (Electronic)9783030252410
ISBN (Print)9783030252403
DOIs
StatePublished - 1 Jan 2019

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2019.

Fingerprint

Dive into the research topics of 'Evolution under antibiotic treatments: Interplay between antibiotic persistence, tolerance, and resistance'. Together they form a unique fingerprint.

Cite this