Evolutional insights on uncharacterized SARS coronavirus genes

Alex Inberg; Michal Linial

doi:10.1016/j.febslet.2004.09.076

Evolutional insights on uncharacterized SARS coronavirus genes

Alex Inberg
, Michal Linial^*

^*Corresponding author for this work

Department of Biological Chemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The complete genome of the severe acute respiratory syndrome coronavirus (SARS-CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC-ORFs). Here, we try to provide a relational insight on those UC-ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC-ORFs exhibit considerable similarity with other SARS-CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS-CoV.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	FEBS Letters
Volume	577
Issue number	1-2
DOIs	https://doi.org/10.1016/j.febslet.2004.09.076
State	Published - 5 Nov 2004

Bibliographical note

Funding Information:
We are grateful to Noam Kaplan and Menachem Fromer for critical reading of the manuscript. This study is supported by The Sudarsky Center for Computational Biology in the Hebrew University and the NoE BioSapience consortium grant.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CoV, coronavirus
Coronavirus
HIV, human immunodeficiency virus
Hypothetical protein
ORF, open reading frame
Proteome
Remote homolog
SARS, severe acute respiratory syndrome
Sequence homology
UC-ORF, uncharacterized open reading frame
Viral evolution

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10.1016/j.febslet.2004.09.076

Cite this

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title = "Evolutional insights on uncharacterized SARS coronavirus genes",

abstract = "The complete genome of the severe acute respiratory syndrome coronavirus (SARS-CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC-ORFs). Here, we try to provide a relational insight on those UC-ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC-ORFs exhibit considerable similarity with other SARS-CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS-CoV.",

keywords = "CoV, coronavirus, Coronavirus, HIV, human immunodeficiency virus, Hypothetical protein, ORF, open reading frame, Proteome, Remote homolog, SARS, severe acute respiratory syndrome, Sequence homology, UC-ORF, uncharacterized open reading frame, Viral evolution",

author = "Alex Inberg and Michal Linial",

note = "Funding Information: We are grateful to Noam Kaplan and Menachem Fromer for critical reading of the manuscript. This study is supported by The Sudarsky Center for Computational Biology in the Hebrew University and the NoE BioSapience consortium grant.",

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AU - Linial, Michal

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N2 - The complete genome of the severe acute respiratory syndrome coronavirus (SARS-CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC-ORFs). Here, we try to provide a relational insight on those UC-ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC-ORFs exhibit considerable similarity with other SARS-CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS-CoV.

AB - The complete genome of the severe acute respiratory syndrome coronavirus (SARS-CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC-ORFs). Here, we try to provide a relational insight on those UC-ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC-ORFs exhibit considerable similarity with other SARS-CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS-CoV.

KW - CoV, coronavirus

KW - Coronavirus

KW - HIV, human immunodeficiency virus

KW - Hypothetical protein

KW - ORF, open reading frame

KW - Proteome

KW - Remote homolog

KW - SARS, severe acute respiratory syndrome

KW - Sequence homology

KW - UC-ORF, uncharacterized open reading frame

KW - Viral evolution

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ER -

Evolutional insights on uncharacterized SARS coronavirus genes

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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