Evolutionary conservation of domain-domain interactions

Zohar Itzhaki, Eyal Akiva, Yael Altuvia, Hanah Margalit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Background: Recently, there has been much interest in relating domain-domain interactions (DDIs) to protein-protein interactions (PPIs) and vice versa, in an attempt to understand the molecular basis of PPIs. Results: Here we map structurally derived DDIs onto the cellular PPI networks of different organisms and demonstrate that there is a catalog of domain pairs that is used to mediate various interactions in the cell. We show that these DDIs occur frequently in protein complexes and that homotypic interactions (of a domain with itself) are abundant. A comparison of the repertoires of DDIs in the networks of Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens shows that many DDIs are evolutionarily conserved. Conclusion: Our results indicate that different organisms use the same 'building blocks' for PPIs, suggesting that the functionality of many domain pairs in mediating protein interactions is maintained in evolution.

Original languageAmerican English
Article numberR125
JournalGenome Biology
Issue number12
StatePublished - 21 Dec 2006


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