Examination of the conformational dynamics of photoregulated Concanavalin a by time-resolved light scattering

Eran Zahavy, Shai Rubin, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Spiropyran-modified Concanavalin A (Con-A) displays photoregulated binding towards α-D-mannopyranoside, the photostimulated binding of the substrate originating from a structural perturbation of the protein upon photoisomerization of spiro-Con-A to the zwitterionic Con-A; time-resolved light scattering reveals that the structural change of the protein involves a shrinkage, and the dynamics of the protein shrinkage depend on the loading of Con-A with spiropyran units.

Original languageEnglish
Pages (from-to)1753-1755
Number of pages3
JournalChemical Communications
Issue number23
DOIs
StatePublished - 1993

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