Exhaustion of calcium does not terminate evoked neurotransmitter release

Hanna Parnas; Lee A. Segel

doi:10.1016/S0022-5193(84)80096-X

Exhaustion of calcium does not terminate evoked neurotransmitter release

Hanna Parnas^*, Lee A. Segel

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Theories are considered which assume that termination of evoked release is caused by the exhaustion of intracellular Ca. It is shown that such theories predict, contrary to experiment, that total release is an unsaturated function of intracellular Ca whose duration depends strongly on extracellular Ca. These and other findings lead to the conclusion that termination must be due to the fast change of another parameter (not intracellular Ca).

Original language	English
Pages (from-to)	345-365
Number of pages	21
Journal	Journal of Theoretical Biology
Volume	107
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5193(84)80096-X
State	Published - 7 Apr 1984

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10.1016/S0022-5193(84)80096-X

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abstract = "Theories are considered which assume that termination of evoked release is caused by the exhaustion of intracellular Ca. It is shown that such theories predict, contrary to experiment, that total release is an unsaturated function of intracellular Ca whose duration depends strongly on extracellular Ca. These and other findings lead to the conclusion that termination must be due to the fast change of another parameter (not intracellular Ca).",

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Exhaustion of calcium does not terminate evoked neurotransmitter release

Abstract

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