Expeditious Synthesis of a Glycopeptide Library

Dror Ben Abba Amiel; Mattan Hurevich

doi:10.1002/ejoc.202200623

Expeditious Synthesis of a Glycopeptide Library

Dror Ben Abba Amiel, Mattan Hurevich^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Short proteoglycan fragments are of great importance for biochemical research. The solid-phase synthesis of such glycopeptides relies on excessive use of glycosylated amino acids, extended reaction times, and additional post-assembly deprotection protocols. We employed high-shear mixing for expedient and equimolar O-glycopeptide assembly. We further developed a stirring-based deprotection on the solid support, thus completing the synthesis of a glycopeptide library in a minimal amount of time and purification hurdles.

Original language	English
Journal	European Journal of Organic Chemistry
DOIs	https://doi.org/10.1002/ejoc.202200623
State	Accepted/In press - 2022

Bibliographical note

Funding Information:
M.H. and D.B.A.A are supported by COST Action 18103 “INNOGLY” and European Innovation Council project “Smellodi” funded by the European Union.

Publisher Copyright:
© 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH.

Keywords

Deacetylation
Glycopeptides
Glycosylated amino acids
Solid-phase synthesis
Synthetic methods

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10.1002/ejoc.202200623

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AU - Hurevich, Mattan

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AB - Short proteoglycan fragments are of great importance for biochemical research. The solid-phase synthesis of such glycopeptides relies on excessive use of glycosylated amino acids, extended reaction times, and additional post-assembly deprotection protocols. We employed high-shear mixing for expedient and equimolar O-glycopeptide assembly. We further developed a stirring-based deprotection on the solid support, thus completing the synthesis of a glycopeptide library in a minimal amount of time and purification hurdles.

KW - Deacetylation

KW - Glycopeptides

KW - Glycosylated amino acids

KW - Solid-phase synthesis

KW - Synthetic methods

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Expeditious Synthesis of a Glycopeptide Library

Abstract

Bibliographical note

Keywords

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