Expeditious Synthesis of a Glycopeptide Library

Dror Ben Abba Amiel, Mattan Hurevich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Short proteoglycan fragments are of great importance for biochemical research. The solid-phase synthesis of such glycopeptides relies on excessive use of glycosylated amino acids, extended reaction times, and additional post-assembly deprotection protocols. We employed high-shear mixing for expedient and equimolar O-glycopeptide assembly. We further developed a stirring-based deprotection on the solid support, thus completing the synthesis of a glycopeptide library in a minimal amount of time and purification hurdles.

Original languageAmerican English
JournalEuropean Journal of Organic Chemistry
StateAccepted/In press - 2022

Bibliographical note

Funding Information:
M.H. and D.B.A.A are supported by COST Action 18103 “INNOGLY” and European Innovation Council project “Smellodi” funded by the European Union.

Publisher Copyright:
© 2022 The Authors. European Journal of Organic Chemistry published by Wiley-VCH GmbH.


  • Deacetylation
  • Glycopeptides
  • Glycosylated amino acids
  • Solid-phase synthesis
  • Synthetic methods


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