Experience-dependent plasticity of mature adult-born neurons

Yoav Livneh, Adi Mizrahi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The adult olfactory bulb and hippocampus are continuously supplied with newborn neurons that are thought to possess a capacity for plasticity only at a young neuronal age, mainly during the early stages of integration into the network. We find that the two main types of adult-born neurons in the mouse olfactory bulb undergo experience-dependent plasticity long after maturation and integration, as evidenced by stabilization of synaptic turnover rates. Thus, the potential time window for plasticity of adult-born neurons extends well into maturity.

Original languageAmerican English
Pages (from-to)26-28
Number of pages3
JournalNature Neuroscience
Issue number1
StatePublished - Jan 2012

Bibliographical note

Funding Information:
We thank H. Spors (Max Planck Institute of Biophysics, Frankfurt, Germany) for the analysis software for the intrinsic signals. We thank Y. Adam for assistance with surgical procedures. We thank members of the Mizrahi laboratory and D. Nachmani for discussions and for commenting on the manuscript. This work was supported by European Research Council (203994) and ERA-NET (0398216) grants to A.M. Y.L. is supported by the Adams Fellowship Program of the Israel Academy of Sciences and Humanities.


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